PRODUCT

Vilon (20 mg Vial)

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Quickstart Highlights

Vilon (Lys‑Glu) is a synthetic immunoregulatory dipeptide consisting of lysine and glutamic acid residues[1]. Preclinical research indicates it may enhance immune markers including CD5+ lymphocytes and interleukin‑2 expression in thymic and splenic cell cultures[2][3]. This educational protocol presents a pulsed subcutaneous approach (5 consecutive days per 4‑week cycle) using a practical dilution for clear insulin‑syringe measurements.

Reconstitute: Add 3.0 mL bacteriostatic water → ~6.67 mg/mL concentration.
Typical range: 67–670 mcg once daily for 5 consecutive days per cycle.
Easy measuring: At 6.67 mg/mL, 1 unit = 0.01 mL ≈ 66.7 mcg on a U‑100 insulin syringe.
Storage: Lyophilized: freeze at −20 °C (−4 °F); after reconstitution, refrigerate at 2–8 °C (35.6–46.4 °F); use within 1 week or aliquot and freeze.

Reconstitution

Draw 3.0 mL bacteriostatic water with a sterile syringe.
Inject slowly down the vial wall; avoid foaming.
Gently swirl/roll until dissolved (do not shake).
Label and refrigerate at 2–8 °C (35.6–46.4 °F) , protected from light; use within ~1 week or aliquot and freeze [10] .
Label and refrigerate at 2–8 °C (35.6–46.4 °F), protected from light; use within ~1 week or aliquot and freeze[10].

Protocol Overview

Goal:Support immune modulation and thymic function markers based on preclinical observations[1][2].
Schedule:5 consecutive days of subcutaneous injections per 4‑week cycle; repeat for 2–4 cycles.
Dose Range:67–667 mcg daily with gradual titration during the first cycle.
Reconstitution:3.0 mL per 20 mg vial (~6.67 mg/mL) for accurate low‑volume measurements.
Storage:Lyophilized frozen; reconstituted refrigerated; avoid repeated freeze–thaw.

Dosage Protocols

Start:67 mcg (1 unit) on Day 1; increase by ~67 mcg (1 unit) each day during first cycle.
Target:333–667 mcg (5–10 units) daily by Cycle 2 onward.
Frequency:Once per day (subcutaneous) for 5 consecutive days per cycle[5].
Cycle Length:5 days on, ~23 days off (4‑week cycle); run 2–4 cycles.
Timing:Any consistent time; rotate injection sites.

Storage Instructions

Lyophilized:Store at −20 °C (−4 °F) short‑term or −80 °C (−112 °F) long‑term in dry, dark conditions; minimize moisture exposure[10].
Reconstituted:Refrigerate at 2–8 °C (35.6–46.4 °F); use within ~1 week or prepare aliquots and freeze to extend stability.

Important Notes

Practical considerations for consistency and safety.

Use new sterile insulin syringes (30‑ or 50‑unit recommended for low‑volume accuracy); dispose in a sharps container.
Rotate injection sites (abdomen, thighs, upper arms) to reduce local irritation[9].
Inject slowly; wait a few seconds before withdrawing the needle.
Document daily dose and site rotation to maintain consistency across cycles.

How It Works

Vilon belongs to a class of short bioregulatory peptides developed through Russian gerontology research[4]. In vitro studies demonstrate that the Lys‑Glu dipeptide can modulate lymphocyte populations and cytokine gene expression. Specifically, Vilon has been observed to increase CD5+ cell counts in thymus cell cultures[1] and upregulate interleukin‑2 (IL‑2) mRNA expression in splenocyte preparations[2]. Additional preclinical work suggests effects on TGF‑β1 and vascular permeability in renal models[3]. The pulsed 5‑day monthly regimen is analogized from related short peptide protocols such as Epitalon[5].

Lifestyle Factors

Pair with a nutrient‑dense diet rich in antioxidants and adequate protein to support immune function.
Incorporate regular moderate exercise to reinforce immune and metabolic health.
Prioritize sleep (7–9 hours) and stress management to optimize endogenous immune regulation.

Injection Technique

Clean the vial stopper and skin with alcohol; allow to dry.
Pinch a skinfold; insert the needle at 45–90° into subcutaneous tissue[7][8].
Do not aspirate for subcutaneous injections; inject slowly and steadily[9].
Rotate sites systematically (abdomen, thighs, upper arms) to avoid lipohypertrophy[9].

Benefits and Side Effects

Benefits

Supports immune cell marker expression (CD5+ lymphocytes) and IL‑2 gene activity in cell culture models[1][2].
May modulate inflammatory cytokines such as TGF‑β1 under experimental renal stress conditions[3].
Early mouse studies suggest potential effects on tumor growth inhibition and lifespan extension, though human data remain limited[6].

Side Effects

Generally well tolerated in preclinical settings; occasional mild injection‑site reactions (redness/itch) may occur with subcutaneous administration.

Vilon (20 mg Vial)

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