PRODUCT

Thymulin

No short description available.

Molecular Info

Chain Length:9 amino acids (nonapeptide)
Sequence Type:Metallopeptide hormone (zinc-dependent)
Molecular Weight:858.86 Da (apo-thymulin); ~922 Da with zinc
Amino Acid Sequence:H-Pyr-Ala-Lys-Ser-Gln-Gly-Gly-Ser-Asn-OH (pGlu-Ala-Lys-Ser-Gln-Gly-Gly-Ser-Asn)
Modification:N-terminal pyroglutamic acid (cyclized glutamine) provides aminopeptidase resistance. Requires 1:1 zinc binding for biological activity. Zinc coordination involves Ser4, Ser8, N-terminal pGlu, and potentially Gln5.

Research Indications

Immunity

moderate

T-Cell Differentiation
Induces T-cell maturation and function in immature lymphoid cells
NK Cell Enhancement
Enhances natural killer cell activity

Inflammation

effective

Cytokine Modulation
Inhibits TNF-α, IL-1β, IL-6 and other pro-inflammatory cytokines
NF-κB Inhibition
Blocks key inflammatory transcription factor

Anti Aging

most_effective

Thymic Support
May address age-related thymulin decline and immunosenescence

Interactions

Zinc Supplementation

Synergistic

Thymulin requires zinc for biological activity (1:1 equimolar binding). Zinc deficiency decreases thymulin activity; supplementation restores it. Co-administration essential for optimal effect.

Thymosin Alpha-1

Compatible

Both are thymic peptides but act through different mechanisms. Thymosin Alpha-1 works via TLR signaling while thymulin requires zinc binding. May be complementary for immune support.

Thymosin Beta-4

Compatible

Different functions -TB-4 focuses on tissue repair while thymulin modulates immune function. No known negative interactions.

Epitalon

Compatible

Complementary anti-aging mechanisms. Epitalon targets telomerase/pineal function while thymulin addresses thymic/immune aging. Often used together in longevity protocols.

Corticosteroids

Monitor Combination

Both have anti-inflammatory effects but different mechanisms. High-dose corticosteroids may suppress thymic function. Thymulin may offer steroid-sparing potential in lung diseases.

NSAIDs

Compatible

PAT (thymulin analog) showed comparable efficacy to indomethacin in animal studies. Different mechanisms -may be additive for pain/inflammation.

BPC-157

Unknown

Both have anti-inflammatory properties through different pathways. No interaction studies available. Theoretically compatible.

Humanin

Unknown

Both involved in aging-related pathways. Different mechanisms. No interaction data available.

Dosage Protocols

Animal Research Protocol (Inflammation):15 μg/100g body weightSingle dose or short course
PAT Analog (Pain Research):25-50 μg per rat (~100-200 μg/kg)30 min before inflammatory challenge
Anecdotal Human Protocol:1-5 mg per injectionOnce daily for 5-10 days

Route:injectable

Reconstitution

Store lyophilized powder at -20°C until use
Allow vial to reach room temperature
Add sterile water slowly down vial side
Gently swirl until dissolved -do not shake
Solution should be clear; discard if cloudy
Use reconstituted solution within 7-10 days
Store reconstituted at 2-8°C
Ensure adequate zinc intake for biological activity

Route:injectable

Thymulin

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