PRODUCT

Selank (5 mg Vial)

No short description available.

Quickstart Highlights

Selank is a synthetic heptapeptide analog of tuftsin with demonstrated anxiolytic and anti-asthenic (energy-boosting) properties in human clinical trials[1][2]. In Russian studies, intranasal Selank produced anxiolytic effects comparable to benzodiazepines without sedation or dependence potential[1]. This educational protocol presents a once‑daily subcutaneous approach using practical dilution for accurate insulin‑syringe measurements.

Reconstitute: Add 3.0 mL bacteriostatic water (max vial capacity) → ~1.67 mg/mL concentration.
Typical daily range: 300–500 mcg once daily subcutaneously (gradual titration).
Easy measuring: At 1.67 mg/mL, 1 unit = 0.01 mL ≈ 16.7 mcg on a U‑100 insulin syringe.
Storage: Lyophilized: freeze at −20 °C (−4 °F); after reconstitution, refrigerate at 2–8 °C (35.6–46.4 °F); avoid freeze–thaw cycles.

Molecular Info

Chain Length:7 amino acids
Sequence Type:Tuftsin analog
Molecular Weight:751.89 Da
Amino Acid Sequence:Thr-Lys-Pro-Arg-Pro-Gly-Pro
Modification:Synthetic analog of tuftsin with anxiolytic properties

Research Indications

Anxiety

effective

Generalized Anxiety Disorder
Clinical trials demonstrate significant reduction in anxiety symptoms comparable to benzodiazepines but without sedation, amnesia, or dependence potential
Post-Traumatic Stress Disorder
Emerging research shows effectiveness in PTSD treatment, helping stabilize stress responses and emotional regulation without cognitive impairment
Social Anxiety and Performance Stress
Reduces anticipatory anxiety and social stress while maintaining cognitive clarity and emotional stability during challenging situations

Cognitive

effective

Memory and Learning Enhancement
Improves memory consolidation and learning processes, particularly effective in subjects with initially poor cognitive performance
Attention and Focus Improvement
Enhances concentration and mental clarity without stimulant effects, beneficial for ADHD-like symptoms and cognitive fatigue
Neuroprotective Effects
Increases BDNF expression supporting neuroplasticity, potentially protective against age-related cognitive decline and neurodegenerative processes

Immune

effective

Immune System Modulation
Balances T-helper cell cytokines and modulates IL-6 expression, supporting healthy immune responses without over-activation
Antiviral Activity
Demonstrated effectiveness against multiple viruses including influenza, herpes simplex, and cytomegalovirus through immune enhancement
Inflammation Regulation
Modulates inflammatory gene expression and reduces chronic inflammation markers while supporting appropriate immune responses

Reconstitution

Draw 3.0 mL bacteriostatic water with a sterile syringe.
Inject slowly down the vial wall; avoid foaming.
Gently swirl/roll until dissolved (do not shake vigorously as peptides are delicate).
Label and refrigerate at 2–8 °C (35.6–46.4 °F) , protected from light.
Label and refrigerate at 2–8 °C (35.6–46.4 °F), protected from light.

Interactions

Semax

Synergistic

Related nootropic peptide - often combined for enhanced cognitive and anxiolytic effects

BPC-157

Compatible

No known interactions, complementary mechanisms for stress response and neural protection

Noopept

Compatible

Both enhance BDNF and cognitive function through different pathways - may complement each other

Phenylpiracetam

Compatible

Selank provides anxiolytic effects while racetams enhance cognitive stimulation

Benzodiazepines

Use Caution

Similar GABAergic effects may potentiate sedation - medical supervision recommended

SSRI Antidepressants

Monitor Combination

Can be combined with SSRIs for enhanced mood regulation - monitor for serotonin effects

Modafinil

Compatible

Selank reduces anxiety while modafinil enhances wakefulness - balanced cognitive enhancement

Alcohol

Avoid Combination

Both affect GABA system - combination may cause excessive sedation or unpredictable effects

Protocol Overview

Goal:Support reduction of anxiety and neurasthenia symptoms while providing anti-asthenic (energy-boosting) benefits[1][2].
Schedule:Daily subcutaneous injections for 4-week cycles with 4-week breaks (8–16 weeks total protocol).
Dose Range:300–500 mcg daily with gradual titration.
Reconstitution:3.0 mL per 5 mg vial (~1.67 mg/mL) for accurate unit measurements.
Storage:Lyophilized frozen; reconstituted refrigerated; avoid repeated freeze–thaw.

Dosage Protocols

Start:300 mcg daily for weeks 1–2; clinicians treating cognitive or anxiety issues often begin at this level[3].
Target:500 mcg daily by weeks 3–4 if lower doses are well-tolerated.
Frequency:Once per day (subcutaneous); some protocols use 5 days per week with 2-day breaks[3].
Cycle Pattern:4 weeks on, 4 weeks off to prevent tachyphylaxis; repeat as needed.
Timing:Any consistent time; rotate injection sites to prevent irritation.

Dosage Protocols

Mild anxiety relief:250mcg dailyOnce daily
Moderate anxiety/cognitive enhancement:250mcg twice dailyMorning and evening
Intensive anxiety/stress management:500mcg dailyDivided doses
Cognitive enhancement/nootropic use:250-350mcg dailyMorning only
PTSD/trauma support:250mcg twice dailyConsistent timing
Immune support during stress:250mcg dailyOnce daily for 2-4 weeks

Route:injectable

Storage Instructions

Lyophilized:Store at −20 °C (−4 °F) for long-term stability (several months); refrigeration at 2–8 °C (35.6–46.4 °F) acceptable for shorter periods[10].
Reconstituted:Refrigerate at 2–8 °C (35.6–46.4 °F); stable for approximately 1 month with minimal potency loss[10]. Prepare aliquots if needed and avoid freeze–thaw cycles.

Important Notes

Practical considerations for consistency and safety.

Use new sterile insulin syringes for each injection; dispose in a sharps container immediately after use[9].
Rotate injection sites (abdomen, thighs, upper arms) systematically to reduce local irritation and prevent tissue changes[7].
Inject slowly and steadily; wait a few seconds before withdrawing the needle.
Document daily dose, timing, and site rotation to maintain consistency throughout the protocol.
Multi-use bacteriostatic water vials should be dated upon opening and discarded within 28 days[9].

Reconstitution

Remove Selank vial from refrigeration and allow to reach room temperature for 10-15 minutes to prevent condensation
Clean vial tops with alcohol wipes using circular motion from center outward, allow to air dry completely
Calculate appropriate reconstitution volume based on desired concentration using the calculator below
Draw calculated amount of bacteriostatic water into insulin syringe, remove any air bubbles
Insert needle into Selank vial at 45-degree angle against the glass wall - do NOT inject directly into powder
Slowly inject BAC water down the side of the vial to minimize foaming and preserve peptide integrity
Remove needle and gently swirl vial - NEVER shake vigorously as this can damage the peptide structure
Allow solution to sit for 1-2 minutes if any cloudiness remains, then swirl gently until completely clear
Final solution should be clear and colorless - persistent cloudiness indicates peptide degradation
Label vial with reconstitution date and concentration, store in refrigerator immediately
Use within 30 days of reconstitution, always inspect for particles before injection

Route:injectable

How It Works

Selank is a synthetic analog of the immunomodulatory peptide tuftsin, consisting of the sequence Thr-Lys-Pro-Arg-Pro-Gly-Pro. In Russian clinical trials for anxiety disorders and neurasthenia, intranasal Selank produced anxiolytic effects comparable to benzodiazepines while also providing anti-asthenic (energy-boosting) benefits without sedative side effects or dependence potential[1][2]. Preclinical studies in primates demonstrated that intranasal Selank eliminated fear and anxiety behaviors with long-term stabilizing effects on neurobehavior[4]. Rodent studies confirmed robust anxiolytic efficacy comparable to classical tranquilizers[5]. While most published human data utilized intranasal dosing (the original formulation), subcutaneous administration has shown effectiveness in research settings with consistent absorption and ease of dose measurement[3].

Lifestyle Factors

Maintain consistent sleep hygiene and aim for 7–9 hours of quality sleep to support neurological function and stress resilience.
Incorporate regular physical activity; both aerobic exercise and resistance training support mood regulation and cognitive performance.
Practice stress-management techniques such as mindfulness, meditation, or breathwork to complement Selank’s anxiolytic effects.
Support nutritional status with adequate protein, omega-3 fatty acids, and micronutrients essential for neurotransmitter synthesis.
Minimize alcohol and stimulant use, which can interfere with anxiety management and neurological stability.

Injection Technique

Wash hands thoroughly and prepare a clean work surface.
Clean the vial stopper with an alcohol swab; allow to dry completely.
Draw the appropriate volume into a sterile insulin syringe; remove air bubbles by flicking the syringe and expelling air.
Clean the injection site with a fresh alcohol swab; allow skin to dry to prevent stinging.
Pinch a skinfold of subcutaneous tissue; insert the needle at 90° into the subcutaneous layer[7].
Do not aspirate for subcutaneous injections; inject slowly and steadily[8].
Withdraw the needle straight out after injection; apply gentle pressure if minor bleeding occurs.
Dispose of the used syringe immediately in an appropriate sharps container; never reuse needles or syringes[9].
Rotate sites systematically (abdomen at least 2 inches from navel, front/outer thighs, upper arms) to avoid lipohypertrophy[7].

Benefits and Side Effects

Benefits

Provides anti-asthenic (energy-boosting) benefits alongside anxiety reduction[2].
Generally well tolerated in clinical studies; a 14-day continuous course was well-tolerated and effective in human trials[2].

Side Effects

Produces anxiolytic effects comparable to benzodiazepines in human clinical trials without sedation or dependence risk[1].
Induces lasting neurobehavioral changes; primate studies showed elimination of fear/anxiety behaviors with long-term stabilizing effects[4].
Occasional mild injection-site reactions (redness, minor irritation) may occur with subcutaneous administration; proper site rotation minimizes this risk.

Selank (5 mg Vial)

Resources

Categories

Company