PRODUCT

Prostamax (20 mg Vial)

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Quickstart Highlights

Prostamax is a synthetic tetrapeptide bioregulator (Lys-Glu-Asp-Pro / KEDP) derived from prostate tissue peptide complex research[1][2]. Short peptides of this class have been studied for their ability to modulate gene expression through epigenetic interactions with chromatin and histones[3][4]. This educational protocol presents a once‑daily intramuscular approach using a practical dilution for clear insulin‑syringe measurements.

Reconstitute: Add 2.0 mL bacteriostatic water → 10 mg/mL concentration.
Typical daily range: 500 mcg–1 mg once daily (gradual titration).
Easy measuring: At 10 mg/mL, 1 unit = 0.01 mL = 100 mcg (0.1 mg) on a U‑100 insulin syringe.
Storage: Lyophilized: refrigerate at 4 °C (39.2 °F) short‑term or freeze at −20 °C (−4 °F) long‑term; after reconstitution, refrigerate at 2–8 °C (35.6–46.4 °F) and use within 2 weeks.

Molecular Info

Chain Length:4 amino acids
Sequence Type:Tetrapeptide
Molecular Weight:487.5 Da
Amino Acid Sequence:Lys-Glu-Asp-Pro (KEDP)
Modification:Synthetic Khavinson peptide bioregulator with prostate tissue specificity

Research Indications

Prostatehealth

effective

Chronic Prostatitis Management
Preclinical studies demonstrate reduced inflammation (swelling, hyperemia, lymphoid infiltration) and prevention of sclerotic/atrophic processes in chronic aseptic prostatitis models
Tissue Regeneration
Enhanced proliferative and metabolic activity in prostate epithelial cells and fibroblasts, maintaining efficacy in aged tissue samples
Superior to Conventional Agents
Preclinical efficacy surpassed Serenoa repens extract and animal prostate-derived medications in comparative studies

Anti Aging

most_effective

Chromatin Decondensation
Induces deheterochromatinization in human lymphocytes, potentially reactivating genes suppressed during aging through pericentromeric chromatin relaxation
Epigenetic Modulation
Affects ribosome gene activation and chromosomal structural patterns (chromosomes 1, 9, 16) in elderly subjects aged 75-88 years
Cellular Aging Research
Part of the Khavinson peptide family studied for geroprotective effects, with long-term Russian clinical protocols showing benefits in elderly populations

Immune

effective

Lymphocyte Function Optimization
Studies show effects on lymphocyte chromatin organization, potentially improving immune cell function through gene expression modulation
Nucleolus Organizer Activation
Heightened Ag-positive nucleolus organizer regions observed, suggesting enhanced ribosomal gene activity

Reconstitution

Draw 2.0 mL bacteriostatic water with a sterile syringe.
Inject slowly down the vial wall; avoid foaming.
Gently swirl/roll until dissolved (do not shake).
Label and refrigerate at 2–8 °C (35.6–46.4 °F) , protected from light; use within 2 weeks.
Label and refrigerate at 2–8 °C (35.6–46.4 °F), protected from light; use within 2 weeks.

Interactions

Epitalon

Compatible

Both are Khavinson bioregulators with complementary mechanisms. Prostamax targets prostate tissue while Epitalon focuses on telomerase activation. Russian protocols combine multiple bioregulators for comprehensive anti-aging support.

Thymalin

Compatible

Safe combination supporting prostate-immune axis. Both are short Khavinson peptides with different tissue specificities. Long-term Russian studies show safety of multi-peptide bioregulator protocols.

Pinealon

Compatible

Different target tissues with no known interactions. Pinealon targets neurological pathways while Prostamax focuses on prostate tissue. Can be used in comprehensive bioregulator protocols.

BPC-157

Compatible

Different mechanisms with no documented interactions. BPC-157 focuses on tissue repair and GI protection while Prostamax provides prostate-specific bioregulation.

5-Alpha Reductase Inhibitors

Use Caution

Both affect prostate tissue - effects may overlap or be amplified. Monitor for enhanced effects and consult healthcare provider if using together.

Testosterone/TRT

Monitor Combination

Both influence prostate tissue. Theoretical concern for combined effects on prostate growth. Monitor PSA levels and prostate symptoms if using together.

Saw Palmetto (Serenoa repens)

Compatible

Preclinical studies compared Prostamax favorably to Serenoa repens extract. Different mechanisms - may provide complementary prostate support.

Protocol Overview

Goal:Support prostate tissue health and function through bioregulatory peptide signaling[1][2].
Schedule:Daily intramuscular injections for 8–12 weeks (extend to 16 weeks if desired).
Dose Range:500 mcg–1 mg daily with gradual titration.
Reconstitution:2.0 mL per 20 mg vial (10 mg/mL) for accurate unit measurements.
Storage:Lyophilized refrigerated or frozen; reconstituted refrigerated; use within 2 weeks.

Dosage Protocols

Start:500 mcg (0.5 mg) daily; increase by ~250 mcg every 2 weeks as tolerated.
Target:1 mg daily by Weeks 5–8.
Frequency:Once per day (intramuscular).
Cycle Length:8–12 weeks; optional extension to 16 weeks.
Timing:Any consistent time; rotate injection sites among large muscle groups.

Dosage Protocols

Prostate Health Support:0.5-1mg dailyOnce daily
Anti-Aging Protocol:0.75mg dailyOnce daily for 10-20 days
Preclinical Reference (Rat Model):20 μg/kgDaily for 15 days

Route:injectable

Storage Instructions

Lyophilized:Proper storage preserves peptide quality[8]. Lyophilized (short‑term): Refrigerate at 4 °C (39.2 °F) in dry, dark conditions. Lyophilized (long‑term): Store at −20 °C (−4 °F) for extended stability. Reconstituted: Refrigerate at 2–8 °C (35.6–46.4 °F); use within ~2 weeks and avoid freeze–thaw cycles. Allow vials to reach room temperature before opening to reduce condensation uptake.
Reconstituted:Refrigerate at 2–8 °C (35.6–46.4 °F); use within ~2 weeks and avoid freeze–thaw cycles.

Important Notes

Practical considerations for consistency and safety.

Use new sterile insulin syringes or appropriate IM syringes; dispose in a sharps container.
Rotate injection sites among large muscle groups (deltoid, vastus lateralis, gluteus) to reduce local irritation[5].
Inject slowly; wait a few seconds before withdrawing the needle.
For volumes ≤10 units, use 30‑ or 50‑unit syringes for better precision.
Document daily dose and site rotation to maintain consistency.

Reconstitution

Remove lyophilized powder from refrigeration and allow to reach room temperature
Clean vial tops with alcohol swabs and allow to dry completely
Add 2.0mL bacteriostatic water to achieve 10mg/mL concentration
Inject water slowly down the side of the vial to minimize foaming
Gently swirl (do not shake) until powder dissolves completely - solution should be clear
Store reconstituted solution in refrigerator at 2-8°C
Use within 14 days of reconstitution for optimal potency

Route:injectable

How It Works

Prostamax (KEDP) belongs to the class of short bioregulatory peptides studied by Khavinson and colleagues. These tetrapeptides are proposed to modulate gene expression through epigenetic mechanisms, interacting with chromatin structure and histone proteins[3][4]. In aged human lymphocytes, KEDP has been observed to cause pericentromeric chromatin decondensation, potentially reactivating suppressed genes[3]. Preclinical rat models of prostatitis showed that IM administration of KEDP reduced inflammatory markers and helped prevent fibrotic changes in prostate tissue[1][2].

Lifestyle Factors

Maintain a balanced diet rich in vegetables, healthy fats, and adequate protein.
Regular physical activity supports circulation and overall metabolic health.
Adequate hydration and limiting alcohol/caffeine may support urinary function.
Prioritize sleep and stress management to support immune and hormonal balance.

Injection Technique

Clean the vial stopper and skin with alcohol; allow to dry completely.
For IM injection, use a 22–25 gauge, 1–1.5 inch needle inserted at 90° into a large muscle (deltoid, vastus lateralis, or gluteus)[5].
Aspiration before IM injection is no longer routinely recommended for most sites[7].
Inject slowly and steadily; wait briefly before withdrawing.
Rotate sites systematically to avoid muscle irritation or fibrosis[9].
Alternative (SC): If subcutaneous route is preferred, use a 23–25 gauge, 5/8 inch needle at 45° into fatty tissue[6].

Benefits and Side Effects

Benefits

In rat prostatitis models, IM KEDP administration reduced inflammation and supported tissue normalization over treatment periods of 15–60 days[1].
Studies in benign prostatic hyperplasia (BPH) models showed favorable effects on prostate weight and histological parameters[2].
Short bioregulatory peptides of this class generally show favorable tolerability profiles in preclinical work[4].
Note: Human clinical trial data are not yet published; dosing is extrapolated from animal models.

Side Effects

Potential for mild injection‑site reactions (redness, tenderness) as with any IM administration; rotate sites to minimize.

Prostamax (20 mg Vial)

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