MGF is a splice variant of IGF-1 that is expressed in muscle tissue following mechanical loading or damage[2]. Unlike systemic IGF-1, MGF acts locally to activate satellite cells and initiate muscle repair processes through its unique C-terminal E peptide domain. Pegylation of MGF extends its half-life, allowing for once-daily subcutaneous administration instead of the frequent local injections required for native MGF. Animal studies have shown that MGF analogues can enhance muscle regeneration, bone healing, and cartilage repair when administered over several weeks.
