PRODUCT

P21

No short description available.

Molecular Info

Chain Length:5 amino acids (with modifications)
Sequence Type:Modified tetrapeptide derivative
Molecular Weight:578.3 Da
Amino Acid Sequence:Ac-DGGLAG-NH2
Modification:N-terminal acetylation and C-terminal adamantylated glycine (AGly) for enhanced BBB penetration and metabolic stability

Research Indications

Cognitive

effective

Memory Enhancement
Preclinical studies demonstrate significant improvements in short-term memory, spatial reference memory, and object recognition in normal and diseased mice.
Learning Acceleration
P21 accelerated spatial learning acquisition in water maze tasks, with treated animals showing faster encoding of platform location.
Neurogenesis Promotion
Enhanced proliferation and maturation of newborn neurons in hippocampal dentate gyrus, critical for memory formation.

Neuroprotection

effective

Alzheimer's Disease
Significantly reduced tau hyperphosphorylation, prevented neurodegeneration, and rescued cognitive deficits in 3xTg-AD mice over 18 months.
Traumatic Brain Injury
Increased newborn neurons by 80%, reversed dendritic/synaptic density loss, and improved memory recall in TBI models.
Age-Related Decline
Restored neurogenesis to levels approaching young adults in aged rats, normalized BDNF/TrkB signaling.

Synaptic

effective

Synaptic Protein Enhancement
Significantly increased synaptophysin and synapsin I expression in hippocampus, supporting enhanced neurotransmitter release.
Glutamate Receptor Upregulation
Increased NMDA (GluN2A) and AMPA (GluA1, GluA2+3) receptor subunits, enhancing synaptic plasticity.
Dendritic Spine Preservation
Protected and restored dendritic spine density in disease and injury models.

Interactions

Adamax

Synergistic

Adamax incorporates adamantyl portion from P21, may complement cognitive benefits through different neuropeptide pathways

Semax

Compatible

Both are neuropeptides with established nootropic effects. Different mechanisms (CNTF vs melanocortin) may provide complementary cognitive benefits

Selank

Compatible

Complementary cognitive and anxiolytic effects through different receptor systems

Dihexa

Use Caution

Both affect neuroplasticity strongly through different pathways (CNTF/BDNF vs HGF/c-Met) - avoid concurrent use without careful cycling

BPC-157

Compatible

Different mechanisms - P21 targets neurogenesis/cognition, BPC-157 focuses on tissue repair and gut-brain axis

Cerebrolysin

Similar

P21 was developed as a defined alternative to Cerebrolysin. Both promote neurogenesis but P21 has defined structure and better BBB penetration

NAD+

Compatible

Complementary mechanisms - NAD+ supports cellular energy metabolism while P21 promotes neurogenesis and synaptic plasticity

Epitalon

Compatible

Different mechanisms - Epitalon targets telomerase/pineal function while P21 focuses on neurogenesis and cognitive enhancement

Dosage Protocols

Cognitive enhancement:100-300mcg1x daily
Neuroprotection:300-500mcg1x daily
Memory support:200-300mcg1x daily
Initial trial/assessment:100mcg1x daily

Route:injectable

Reconstitution

Clean work area and hands thoroughly with alcohol
Calculate required BAC water volume using calculator below
Draw calculated BAC water into syringe
Inject slowly down vial side (not directly onto powder)
Gently swirl until completely dissolved (never shake vigorously)
Store reconstituted solution in refrigerator at 2-8°C
Use within 14-30 days for optimal potency

Route:injectable

P21

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