PRODUCT

Ovagen (20 mg Vial)

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Quickstart Highlights

Ovagen is a synthetic ultrashort tripeptide (Glu-Asp-Leu; EDL) studied as a bioregulator of gastrointestinal and liver tissues[1]. In vitro studies demonstrate that EDL increases cell proliferation and modulates aging-related gene markers (p16, p21, p53, SIRT-6) in renal cell cultures[2]. No controlled human trials exist; available data are preclinical and cell-based. This educational protocol presents a once-daily subcutaneous approach with gradual titration using microgram-level dosing.

Reconstitute: Add 2.0 mL bacteriostatic water → 10 mg/mL (10,000 μg/mL) concentration.
Typical daily range: 10–150 μg once daily (gradual titration over 16 weeks).
Easy measuring: At 10 mg/mL, 1 unit = 0.01 mL = 100 μg on a U-100 insulin syringe.
Storage: Lyophilized: freeze at −20 °C (−4 °F); after reconstitution, refrigerate at 2–8 °C (35.6–46.4 °F); avoid freeze–thaw cycles.

Reconstitution

Draw 2.0 mL bacteriostatic water with a sterile syringe.
Inject slowly down the vial wall; avoid foaming.
Gently swirl/roll until dissolved (do not shake).
Label and refrigerate at 2–8 °C (35.6–46.4 °F) , protected from light.
Label and refrigerate at 2–8 °C (35.6–46.4 °F), protected from light.

Protocol Overview

Goal:Support gastrointestinal and hepatic tissue bioregulation over time[1].
Schedule:Daily subcutaneous injections for 16 weeks with gradual titration.
Dose Range:10–150 μg daily with slow escalation.
Reconstitution:2.0 mL per 20 mg vial (10 mg/mL) for precise microgram measurements.
Storage:Lyophilized frozen; reconstituted refrigerated; avoid repeated freeze–thaw.

Dosage Protocols

Start:10 μg daily for Weeks 1–2; increase to 20 μg for Weeks 3–4.
Frequency:Once per day (subcutaneous).
Timing:Any consistent time; rotate injection sites.

Storage Instructions

Lyophilized:Store at −20 °C (−4 °F) or colder in dry, dark conditions; for long-term stability, −80 °C (−112 °F) is optimal.
Reconstituted:Refrigerate at 2–8 °C (35.6–46.4 °F); use within a few days or aliquot and freeze to minimize hydrolysis.

Important Notes

Practical considerations for consistency and safety.

Use new sterile insulin syringes (30-unit or 50-unit preferred for low-volume accuracy); dispose in a sharps container.
Rotate injection sites (abdomen, thighs, upper arms) to reduce local irritation.
Inject slowly; wait a few seconds before withdrawing the needle.
Document daily dose and site rotation to maintain consistency.
Label the vial with date/time of reconstitution, diluent volume, final concentration, and initials[4].

How It Works

Ovagen (EDL) is an ultrashort peptide believed to enter cells and bind DNA, thereby modulating gene expression and protein synthesis[1][6]. In vitro studies show EDL increases cell proliferation and alters aging-related gene markers (p16, p21, p53, SIRT-6) in renal cell cultures, suggesting cytoprotective effects[2]. Such ultrashort peptides are known to influence cell differentiation, proliferation, and apoptosis via gene regulation[3]. Additionally, EDL has been identified as an HIV-1 protease inhibitor with binding affinity in the enzyme active site[7].

Lifestyle Factors

Pair with a balanced diet supporting gastrointestinal and liver health.
Maintain regular physical activity to support overall metabolic function.
Prioritize sleep and stress management to support adherence and recovery.
Avoid excessive alcohol and hepatotoxic substances during the protocol.

Injection Technique

Clean the vial stopper and skin with 60–70% alcohol; allow to dry[8].
Pinch a skinfold; insert the needle at 45–90° into subcutaneous tissue[9][10].
Do not aspirate for subcutaneous injections; inject slowly and steadily[8].
Rotate sites systematically (abdomen, thighs, upper arms) to avoid tissue irritation; keep at least ~2 cm between injections on the same area.
Use a 23–25 gauge needle (5/8″ length) or standard insulin syringe needles (28–31G)[10].

Benefits and Side Effects

Benefits

May support gastrointestinal and hepatic tissue bioregulation based on ultrashort peptide bioregulator research[1].
In vitro studies indicate potential cytoprotective effects via modulation of aging-related gene expression[2].
Ultrashort peptides generally exhibit rapid metabolism and low immunogenicity[6].

Ovagen (20 mg Vial)

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