PRODUCT

Kisspeptin (10 mg Vial)

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Quickstart Highlights

Kisspeptin (also known as metastin) is a naturally occurring neuroendocrine peptide that plays a pivotal role in human reproduction by stimulating gonadotropin-releasing hormone (GnRH) secretion[1]. This small peptide binds to the GPR54 receptor in the hypothalamus, triggering pulsatile GnRH release and downstream secretion of luteinizing hormone (LH) and follicle-stimulating hormone (FSH)[2]. Originally identified as a metastasis-suppressor gene product, kisspeptin has become a major focus in reproductive endocrinology[3]. This educational protocol presents a once-daily subcutaneous approach for research use.

Reconstitute: Add 3.0 mL bacteriostatic water → ~3.33 mg/mL concentration.
Typical daily range: 100–200 mcg once daily (gradual titration).
Easy measuring: At 3.33 mg/mL, 1 unit = 0.01 mL ≈ 33.3 mcg on a U‑100 insulin syringe.
Storage: Lyophilized: freeze at −20 °C (−4 °F); after reconstitution, refrigerate at 2–8 °C (35.6–46.4 °F); avoid freeze–thaw cycles.

Molecular Info

Chain Length:10-54 amino acids
Sequence Type:Neuropeptide family (RFamide)
Molecular Weight:1,213.42 Da (KP-10) / 6,087 Da (KP-54)
Amino Acid Sequence:Kisspeptin-10: Tyr-Asn-Trp-Asn-Ser-Phe-Gly-Leu-Arg-Phe-NH2 | Kisspeptin-54: 54 amino acid C-terminal fragment
Modification:C-terminally amidated peptides derived from 145 amino acid KISS1 precursor protein

Research Indications

Reproductive

effective

Hypogonadotropic Hypogonadism
Research demonstrates kisspeptin can restore reproductive hormone secretion in patients with functional or congenital hypogonadotropic hypogonadism.
IVF Ovulation Trigger
Kisspeptin-54 successfully triggers oocyte maturation in IVF with safer profile than hCG, particularly for OHSS high-risk patients.
Hypothalamic Amenorrhea
Clinical trials show kisspeptin can restore reproductive hormone pulsatility in women with hypothalamic amenorrhea.

Sexual

effective

Hypoactive Sexual Desire Disorder
RCTs demonstrate kisspeptin modulates sexual brain processing and enhances libido markers in both men and women with HSDD.
Sexual Brain Processing
Brain imaging reveals kisspeptin activates sexual arousal centers while deactivating self-monitoring regions.
Libido Enhancement
Clinical evidence shows improvements in sexual desire, arousal, and satisfaction measures with kisspeptin administration.

Metabolic

effective

Energy Metabolism
Preclinical research suggests kisspeptin signaling influences energy expenditure and locomotor activity.
Glucose Homeostasis
Animal studies indicate kisspeptin receptor signaling affects glucose tolerance and insulin sensitivity.
Body Composition
Research shows kisspeptin signaling may influence body weight regulation and adiposity, particularly in females.

Reconstitution

Draw 3.0 mL bacteriostatic water with a sterile syringe.
Inject slowly down the vial wall; avoid foaming.
Gently swirl/roll until dissolved (do not shake).
Label and refrigerate at 2–8 °C (35.6–46.4 °F) , protected from light.
Label and refrigerate at 2–8 °C (35.6–46.4 °F), protected from light.

Interactions

GnRH

Synergistic

Kisspeptin stimulates GnRH release, working upstream in the reproductive axis

hCG

Alternative

Kisspeptin may serve as safer alternative to hCG for IVF ovulation trigger

Testosterone

Compatible

May help restore natural testosterone production through LH stimulation

Estrogen

Compatible

Kisspeptin function is modulated by sex steroids in feedback loops

Protocol Overview

Goal:Support physiological reproductive hormone signaling through upstream GnRH stimulation[1].
Schedule:Daily subcutaneous injections for 8–12 weeks.
Dose Range:100–200 mcg daily with gradual titration.
Reconstitution:3.0 mL per 10 mg vial (~3.33 mg/mL) for precise low-volume measurements.
Storage:Lyophilized frozen; reconstituted refrigerated; avoid repeated freeze–thaw.

Dosage Protocols

Start:100 mcg daily for 1–2 weeks to assess sensitivity[4].
Frequency:Once per day (subcutaneous).
Cycle Length:8–12 weeks; avoid prolonged continuous use to prevent tachyphylaxis[6].
Timing:Any consistent time; rotate injection sites.

Storage Instructions

Lyophilized:Store at −20 °C (−4 °F) in dry, dark conditions with desiccant if possible[15].
Reconstituted:Refrigerate at 2–8 °C (35.6–46.4 °F); stable up to ~4 weeks[16]; avoid freeze–thaw.

Dosage Protocols

Gonadotropin stimulation:100-200mcgSingle dose or 2-3x/week
Fertility support:0.4-1.0 nmol/kg (50-150mcg)As directed by physician
Sexual function:1 nmol/kg/h75 min IV infusion (clinical)
Research protocols:0.3-10 nmol/kgVariable by protocol

Route:injectable

Important Notes

Practical considerations for consistency and safety.

Use new sterile insulin syringes; dispose in a sharps container.
Rotate injection sites (abdomen, thighs, upper arms) to reduce local irritation[13].
Inject slowly; wait a few seconds before withdrawing the needle.
Document daily dose and site rotation to maintain consistency.
Discard bacteriostatic water after 28 days once opened[17].

Reconstitution

Clean work area and hands thoroughly with alcohol
Calculate required BAC water volume using calculator below
Draw calculated BAC water into syringe
Inject slowly down vial side (not directly onto powder)
Gently swirl until completely dissolved (never shake)
Store reconstituted solution in refrigerator at 2-8°C
Use within 7 days for KP-10, up to 14 days for KP-54

Route:injectable

How It Works

Kisspeptin is an upstream trigger for the reproductive hormone cascade. Upon subcutaneous injection, kisspeptin rapidly binds to kisspeptin receptors (GPR54) on GnRH neurons in the hypothalamus, causing immediate release of GnRH[7]. This in turn stimulates the anterior pituitary to secrete LH and FSH, which act on the gonads to boost sex steroid production and support gametogenesis[8]. Importantly, kisspeptin’s action is GnRH-dependent—if GnRH release is blocked, kisspeptin cannot induce LH/FSH secretion[9]. This confirms that kisspeptin works by unlocking the body’s own GnRH stores, providing a more physiologic pattern of hormone release compared to direct GnRH or hCG administration[10].

Lifestyle Factors

Maintain adequate nutrition and healthy body weight to support endogenous hormone production.
Prioritize sleep and stress management, as these factors significantly impact the HPG axis.
Monitor for changes in reproductive function or hormone-related symptoms.
Consider combining with appropriate lifestyle interventions for conditions of hypothalamic suppression.

Injection Technique

Clean the vial stopper and skin with alcohol; allow to dry completely.
Pinch a skinfold; insert the needle at 45–90° into subcutaneous tissue (45° for thin individuals, 90° with adequate fat)[18].
Do not aspirate for subcutaneous injections; inject slowly and steadily[19].
Rotate sites systematically (abdomen at least 2 inches from navel, outer thighs, upper arms, upper buttocks) to avoid tissue irritation[13].
Use a new sterile syringe for each injection; dispose of used syringes in a proper sharps container[20].

Kisspeptin (10 mg Vial)

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