PRODUCT

Humanin (10 Mg)

No short description available.

Quickstart Highlights

Humanin is a 24-amino acid mitochondrial peptide investigated for its ability to support cellular survival and protect against biological stress. Unlike many peptides that target a single pathway, Humanin acts through multiple mechanisms involved in mitochondrial function, cellular energy production, protection against apoptosis, and the cellular stress response. Preclinical research has demonstrated promising results in models of neurodegenerative diseases, metabolic disorders, cardiovascular disease, and healthy aging. Humanin is currently intended exclusively for laboratory research and has not been approved for therapeutic use in humans.

Reconstitution: Add 2.0 mL of bacteriostatic water to a 10 mg vial to obtain a final concentration of approximately 5 mg/mL (5,000 mcg/mL) for convenient dosing.
Typical Range: 200–750 mcg once daily; advanced research protocols may use 1–2 mg daily in limited cycles.
Easy Measurement: At 5 mg/mL, each 1 unit (0.01 mL) on a U-100 insulin syringe delivers approximately 50 mcg.
Storage: Lyophilized product: store frozen at −20 °C (−4 °F). After reconstitution, refrigerate at 2–8 °C (35.6–46.4 °F) and use within 4 weeks.

Reconstitution

Draw 2.0 mL of bacteriostatic water using a sterile syringe.
Slowly inject the diluent down the inside wall of the vial to minimize foaming and preserve peptide integrity.
Gently swirl or roll the vial until the lyophilized powder has completely dissolved. Do not shake vigorously.
Ensure the solution is clear and free of visible particles before use.
Label the vial with the reconstitution date.
Store refrigerated at 2–8 °C (35.6–46.4 °F), protected from light, and use within 4 weeks after reconstitution.

Protocol Overview

Objective:Support research into mitochondrial function, cellular energy production, cellular resilience, and protection against oxidative stress.
Schedule:Daily subcutaneous injections for 4–8 weeks, followed by a rest period to help maintain biological responsiveness.
Dosage Range:200–750 mcg daily for standard research protocols; 1–2 mg daily for advanced protocols.
Reconstitution:Add 2.0 mL of bacteriostatic water to each 10 mg vial to obtain a final concentration of approximately 5 mg/mL (5,000 mcg/mL).
Storage:Store the lyophilized product frozen at −20 °C (−4 °F). After reconstitution, refrigerate at 2–8 °C (35.6–46.4 °F) and use within 4 weeks.

Dosage Protocols

Starting Protocol:200–300 mcg daily for 4–6 weeks to assess individual tolerance.
Standard Protocol:500–750 mcg daily, administered once daily or divided into morning and evening doses if preferred.
Advanced Protocol:1–2 mg daily for 8–12 weeks, intended only for advanced research protocols.
Frequency:Once daily by subcutaneous injection; maintain a consistent administration schedule whenever possible.
Cycle Duration:Typically 4–8 weeks, followed by a 2–6 week rest period depending on the protocol.
Administration Time:Preferably in the morning; some protocols divide the daily dose into two administrations.

Storage Instructions

Lyophilized:Store at −20 °C (−4 °F) in the original sealed vial. Keep in a dry, dark environment and minimize exposure to moisture.
Reconstituted:Refrigerate at 2–8 °C (35.6–46.4 °F) immediately after reconstitution. For optimal stability, use within 4 weeks.

Important Notes

Use a new sterile insulin syringe for every injection and dispose of it immediately in an approved sharps container.
Rotate injection sites systematically (abdomen, outer thighs, upper arms, and upper buttocks) to help reduce local irritation and minimize the risk of lipohypertrophy.
Inject slowly over several seconds and wait briefly before removing the needle to help reduce solution leakage.
Mild injection-site reactions, such as redness, itching, or temporary discomfort, may occur and are generally short-lived.
Record each dose, injection site, and any observations throughout the research protocol to maintain consistency.
Humanin is intended for laboratory research only and has not been approved for therapeutic use in humans.
Individuals with active cancer, pregnancy, breastfeeding, or severe autoimmune diseases should not be included in research protocols unless specifically authorized under appropriate research oversight.

How It Works

Humanin is a mitochondrial-derived peptide (MDP) with a unique multimodal mechanism of action that supports cellular protection and resilience. It functions both as an extracellular signaling molecule and an intracellular protective factor, activating multiple pathways involved in cell survival. Humanin interacts with specific receptor complexes to stimulate protective signaling pathways such as JAK2/STAT3 while also binding to proteins involved in apoptosis, including BAX and IGFBP-3, helping reduce programmed cell death. In addition, Humanin promotes mitochondrial biogenesis through AMPK and PGC-1α activation, improving mitochondrial efficiency, ATP production, and resistance to oxidative stress. These mechanisms have made Humanin an important focus of preclinical research in neurodegenerative diseases, cardiovascular health, metabolic disorders, and healthy aging.

Lifestyle Factors

Nutrition: Prioritize a balanced diet rich in high-quality protein, fruits, vegetables, and healthy fats to support normal cellular metabolism and mitochondrial function.
Exercise: Combine resistance training with regular aerobic exercise to promote mitochondrial health, improve metabolic efficiency, and support overall physical performance.
Sleep: Aim for 7–9 hours of quality sleep each night to support cellular repair, mitochondrial maintenance, and recovery.
Stress Management: Chronic stress may negatively affect mitochondrial function. Incorporate stress-reduction practices such as meditation, breathing exercises, or yoga.
Healthy Habits: Humanin is intended to complement research protocols and should not be considered a substitute for proper nutrition, regular exercise, adequate sleep, or appropriate medical care.

Injection Technique

Site Preparation: Clean the vial stopper and the injection site with an alcohol swab. Allow the alcohol to air-dry completely for 30–60 seconds before proceeding.
Drawing the Dose: Use a new sterile insulin syringe for each injection. Draw the prescribed volume from the refrigerated vial and remove any visible air bubbles by gently tapping the syringe.
Injection Angle: Pinch a fold of skin approximately 1–2 inches (2.5–5 cm) thick. Insert the needle at a 45° to 90° angle, depending on the thickness of the subcutaneous tissue (90° for most adults and 45° for very lean individuals).
Administration: Do not aspirate before a subcutaneous injection. Inject the solution slowly and steadily over 3–5 seconds. Wait 5–10 seconds before withdrawing the needle to minimize leakage.
Site Rotation: Rotate injection sites systematically between the abdomen (at least 2 inches / 5 cm away from the navel), outer thighs, back of the upper arms, and upper buttocks to help prevent lipohypertrophy and local irritation.
Post-Injection: Apply gentle pressure with a clean alcohol swab, gauze, or cotton ball for a few seconds. Do not massage the injection site. Apply a small adhesive bandage if needed.
Disposal: Immediately dispose of the used syringe in an approved sharps container. Do not recap the needle or dispose of it in household trash.

Humanin (10 Mg)

Resources

Categories

Company