PRODUCT

HMG (0.15 mg / 75 IU Vial)

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Quickstart Highlights

Human Menopausal Gonadotropin (HMG) is a purified gonadotropin preparation containing equal amounts of follicle-stimulating hormone (FSH) and luteinizing hormone (LH) activity[1][2]. In males, HMG is used alongside hCG to stimulate spermatogenesis in cases of hypogonadotropic hypogonadism or infertility[3][4]. This educational protocol presents a thrice-weekly subcutaneous approach for male fertility support.

Reconstitute: Add 3.0 mL bacteriostatic water → 25 IU/mL concentration.
Typical protocol: 75 IU three times weekly for 12–16 weeks, usually combined with hCG therapy.
Volume consideration: Each 75 IU dose = 3.0 mL, requiring a 3 mL syringe or multiple 1 mL injections.
Storage: Lyophilized: refrigerate at 2–8 °C (35.6–46.4 °F); after reconstitution, use promptly or refrigerate and use within a few days.

Reconstitution

Draw 3.0 mL bacteriostatic water with a sterile 3 mL syringe.
Inject slowly down the vial wall to avoid foaming.
Gently swirl or roll the vial until fully dissolved (do not shake).
Label with date and time; refrigerate at 2–8 °C (35.6–46.4 °F) , protected from light.
Label with date and time; refrigerate at 2–8 °C (35.6–46.4 °F), protected from light.

Protocol Overview

Goal:Stimulate spermatogenesis in males with hypogonadotropic hypogonadism or infertility[3][4].
Schedule:Subcutaneous injections three times weekly for minimum 12 weeks (extend to 16 weeks if needed)[7].
Dose:75 IU (0.15 mg) per injection, typically combined with hCG therapy[5][6].
Reconstitution:3.0 mL per 75 IU vial (25 IU/mL) for calculation convenience.
Storage:Lyophilized refrigerated; reconstituted solution used promptly or within days when refrigerated.

Dosage Protocols

Dose:75 IU three times per week (e.g., Monday, Wednesday, Friday).
Cycle Length:Minimum 12 weeks; may extend to 16 weeks based on response[7].
Timing:Maintain consistent injection days; rotate sites with each injection.

Storage Instructions

Lyophilized:Proper storage maintains HMG stability and potency. Lyophilized (unopened): Store at 2–8 °C (35.6–46.4 °F) away from light; stable at controlled room temperature up to 25 °C (77 °F)[9]. Reconstituted: Refrigerate at 2–8 °C (35.6–46.4 °F); for best potency use promptly (official guidance recommends immediate use with plain diluent)[9]. With bacteriostatic water, reconstituted solution may be refrigerated and used within a few days. Protect from light at all times; discard any unused solution if not used within recommended timeframe.
Reconstituted:Refrigerate at 2–8 °C (35.6–46.4 °F); for best potency use promptly (official guidance recommends immediate use with plain diluent)[9]. With bacteriostatic water,

Important Notes

Practical considerations for safe and effective administration.

HMG therapy typically requires concurrent hCG administration for optimal results in males[5][6].
Use new sterile syringes for each injection; dispose in a sharps container[10].
Rotate injection sites (abdomen, thighs, upper arms) at least 1 inch apart to prevent lipohypertrophy or irritation[11].
The 3.0 mL injection volume may require splitting into multiple smaller injections or using larger-capacity syringes.
Monitor semen parameters and hormone levels throughout therapy to assess response.
Clinical response typically requires at least 12 weeks; spermatogenesis may take 3–6 months to fully develop[7].

How It Works

HMG provides both FSH and LH activity in a 1:1 ratio, derived from purified human menopausal urine[1][2]. In males with hypogonadotropic hypogonadism, FSH stimulation is essential for spermatogenesis (sperm production)[3]. When hCG alone fails to induce adequate sperm production, adding HMG provides the necessary FSH activity to support testicular function and fertility[5][6]. Clinical studies demonstrate that HMG combined with hCG significantly improves sperm parameters including motility, morphology, and concentration, with enhanced pregnancy rates in treated couples[7][12].

Lifestyle Factors

Maintain healthy body weight and balanced nutrition rich in antioxidants (zinc, selenium, vitamin C, vitamin E).
Avoid excessive heat exposure to testes (hot tubs, saunas, tight clothing).
Limit alcohol consumption and avoid tobacco and recreational drugs.
Manage stress through adequate sleep, exercise, and relaxation techniques.
Regular moderate exercise supports hormonal balance (avoid excessive endurance training).
Consider coenzyme Q10, L-carnitine, or other evidence-based supplements after consultation.

Injection Technique

Wash hands thoroughly and gather supplies on a clean surface.
Clean the vial stopper with an alcohol swab and allow to dry.
Draw up the prescribed dose using a sterile syringe (3 mL capacity for full 75 IU dose).
Select an injection site with adequate subcutaneous fat (lower abdomen at least 2 inches from navel, outer thigh, or upper arm).
Clean the injection site with a fresh alcohol swab; let dry completely.
Pinch about an inch of skin to create a fold of subcutaneous tissue.
Insert needle at a 90° angle (or 45° if very little subcutaneous fat) into the tissue[10][11].
Release the pinch and slowly inject the medication over several seconds.
Withdraw the needle smoothly and apply gentle pressure with sterile gauze (do not rub the site).
Dispose of used syringe immediately in a sharps container[10].
Rotate injection sites with each administration, maintaining at least 1 inch spacing from previous sites[11].

Benefits and Side Effects

Benefits

Observations from clinical fertility literature.

HMG (0.15 mg / 75 IU Vial)

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