PRODUCT

HCG (Human Chorionic Gonadotropin)

No short description available.

Molecular Info

Chain Length:237 amino acids total (alpha: 92 aa + beta: 145 aa)
Sequence Type:Heterodimeric glycoprotein with two non-covalently linked subunits
Molecular Weight:36,700 Da (36.7 kDa)
Amino Acid Sequence:Alpha subunit (92 aa): identical to LH, FSH, and TSH alpha subunits. Beta subunit (145 aa): unique to HCG with 24 aa C-terminal extension not found in LH. Heavy glycosylation (~30% carbohydrate content)
Modification:Extensive N-linked and O-linked glycosylation. The glycan chains extend half-life and influence receptor binding. Urinary-derived (e.g., Pregnyl) vs recombinant (e.g., Ovidrel) forms differ in glycosylation patterns

Research Indications

Growthhormone

effective

Hypogonadotropic Hypogonadism
FDA-approved for secondary hypogonadism to stimulate testosterone production
Testosterone Support
Indirectly supports body composition by maintaining testosterone levels

Recovery

effective

Fertility Preservation
Maintains spermatogenesis and testicular function during TRT
TRT Adjunct
Commonly used to maintain testicular function and fertility during testosterone replacement

Body Composition

moderate

Cryptorchidism Treatment
FDA-approved for undescended testes in prepubertal boys
Ovulation Induction
FDA-approved to trigger ovulation in assisted reproduction

Interactions

Testosterone

Synergistic - Common Combination

HCG is frequently used alongside TRT to maintain testicular function, preserve fertility, and prevent atrophy. Standard TRT protocol: 250-500 IU HCG twice weekly

Clomiphene (Clomid)

Use Sequentially

Both stimulate testosterone production via different mechanisms. Sometimes used sequentially in PCT protocols. Generally not combined simultaneously - choose one approach

Aromatase Inhibitors

Commonly Combined

HCG increases intratesticular aromatase activity and may elevate estrogen. AIs like anastrozole are often used concurrently to manage estrogen levels during TRT+HCG protocols

GnRH Analogs

Monitor Combination

GnRH agonists/antagonists suppress LH. HCG may be used to maintain testicular function during GnRH analog therapy or for recovery afterward. Timing coordination required

FSH (Follitropin)

Synergistic for Fertility

Combined HCG + FSH therapy is standard for male infertility treatment in hypogonadotropic hypogonadism, achieving spermatogenesis in 70-90% of patients

Kisspeptin

Complementary Mechanisms

Both stimulate the HPG axis via different mechanisms. Kisspeptin acts upstream at the hypothalamus while HCG acts directly on gonads. Potentially synergistic for fertility restoration

Thyroid Hormones

Monitor Required

High-dose HCG has weak TSH-like activity due to alpha subunit homology. Can cause transient hyperthyroidism with very high HCG levels (pregnancy, tumors). Monitor thyroid function

Metformin

Protective Combination

In women with PCOS undergoing ovulation induction, metformin may reduce ovarian hyperstimulation syndrome risk when combined with HCG. Often used together in fertility protocols

Dosage Protocols

TRT Adjunct (Low Dose):250-500 IUEvery other day
TRT Adjunct (Standard):500-1000 IUTwice weekly
HCG Monotherapy (Hypogonadism):1500-2000 IU2-3 times weekly
Fertility Protocol (with FSH):1500-2000 IU2-3 times weekly
Cryptorchidism (Pediatric):1000-5000 IU (age-dependent)2-3 times weekly x 3-4 weeks
Ovulation Trigger (Female):5000-10,000 IU single doseOnce (timed with follicle maturity)
PCT Protocol:1000-1500 IUEvery other day x 2-3 weeks

Route:injectable

Reconstitution

Remove HCG vial and diluent from packaging
Clean the rubber stoppers of both vials with alcohol swabs
Draw the diluent (typically 1-2 mL provided) into syringe
Slowly inject diluent into HCG vial, aiming at the vial wall
Gently swirl to dissolve - do not shake vigorously
Allow to sit until completely dissolved and solution is clear
Calculate concentration: e.g., 5000 IU in 2 mL = 2500 IU/mL
Label vial with reconstitution date and concentration
Store reconstituted HCG in refrigerator at 2-8°C
Use within 30-60 days (depending on diluent and product)

Route:injectable

HCG (Human Chorionic Gonadotropin)

Resources

Categories

Company