GHK-Cu is a naturally occurring tripeptide that complexes with copper ions to modulate numerous biological processes. Research has demonstrated its involvement in wound healing through enhanced collagen and decorin gene expression[1], activation of tissue remodeling pathways[2], and regulation of genes associated with antioxidant defense and anti-inflammatory responses[3][4]. Preclinical studies show GHK-Cu is active at very low doses in animals (approximately 0.5 mcg/kg in rodent models)[15], while clinical practice employs milligram-range dosing in humans to achieve systemic effects[5][6]. The peptide demonstrates multifunctional activity across skin, nervous system, and vascular tissue, with documented gene-regulatory effects that extend beyond simple wound healing[3][16].
