PRODUCT

Dihexa

No short description available.

Chain Length:Modified tripeptide with hexanoic acid
Sequence Type:Oligopeptide
Molecular Weight:504.7 Da
Amino Acid Sequence:Hexanoyl-Tyr-Ile-Ahx-NH2 (N-hexanoic-Tyr-Ile-(6)-aminohexanoic amide)
Modification:N-terminal hexanoic acid modification for BBB penetration and metabolic stability

Cognitive

effective

Memory Enhancement
Significant improvements in spatial memory, working memory, and memory consolidation demonstrated across multiple animal models.
Learning Acceleration
Enhanced acquisition of new information and skills through increased synaptic plasticity and neurogenesis.
Cognitive Recovery
Restoration of cognitive function in models of impairment, including scopolamine-induced amnesia and age-related decline.

Neuroprotection

effective

Alzheimer's Disease
Reduced amyloid burden, decreased neuroinflammation, and cognitive rescue in APP/PS1 mouse models.
Synaptic Preservation
Protection and restoration of synaptic connections in neurodegenerative disease models.
Anti-inflammatory Effects
Reduction of IL-1β and TNF-α, increased IL-10, and decreased glial activation in brain tissue.

Neuroplasticity

effective

Synaptogenesis
Dramatic increase in dendritic spine formation, up to 3-fold in hippocampal neurons.
BDNF Upregulation
Indirect enhancement of brain-derived neurotrophic factor signaling through HGF/c-Met activation.
Angiogenesis
Promotion of new blood vessel formation in brain tissue through VEGFR2 activation.

Semax

Compatible

Can be stacked for enhanced cognitive benefits but requires careful cycling to avoid overstimulation

Selank

Compatible

Synergistic cognitive and anxiolytic effects when combined, but monitor for neural overstimulation

BPC-157

Compatible

No known negative interactions - different mechanisms of action

P21

Use Caution

Both affect neuroplasticity strongly - avoid concurrent use without careful cycling

Noopept

Compatible

Some users stack for cognitive enhancement but limited safety data on combination

NAD+

Compatible

Complementary mechanisms - NAD+ supports cellular energy while Dihexa promotes synaptogenesis

Cerebrolysin

Use Caution

Both are potent neurotrophic agents - combining may lead to excessive stimulation

TB-500

Compatible

No known interactions - TB-500 focuses on tissue repair while Dihexa targets neural connections

Resources