Cortagen (Ala-Glu-Asp-Pro) is a synthetic tetrapeptide derived from amino acid analysis of the natural brain cortex preparation Cortexin[3]. It acts as a gene expression modulator and epigenetic regulator, influencing the synthesis of proteins involved in neuronal growth, differentiation, and stress resistance[6][7]. Preclinical studies demonstrate that Cortagen can upregulate neurotrophic factors, reduce oxidative stress markers, and accelerate peripheral nerve regeneration—increasing nerve fiber growth rate and conduction velocity by 27–40% in injury models[1]. In chronic cerebral ischemia models, Cortagen improved behavioral recovery and protected against oxidative damage[2].
