PRODUCT

AOD-9604 (2 mg Vial)

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Quickstart Highlights

AOD-9604 dosage protocols leverage this synthetic 16‑amino‑acid fragment (Tyr‑hGH 177–191) to support lipolysis (fat breakdown) and inhibit lipogenesis (fat storage) without elevating IGF‑1 levels or causing insulin resistance[1][2]. Clinical trials have demonstrated that AOD‑9604 exhibits a placebo‑like safety profile in obese adults, making it a well‑tolerated option for metabolic support[3]. This educational protocol outlines a once‑daily subcutaneous approach using a practical dilution for clear insulin‑syringe measurements.

Reconstitute: Add 3.0 mL bacteriostatic water → ~0.667 mg/mL (667 mcg/mL) concentration.
Typical daily range: 300–500 mcg once daily (gradual titration).
Easy measuring: At 0.667 mg/mL, 1 unit = 0.01 mL ≈ 6.67 mcg on a U‑100 insulin syringe.
Storage: Lyophilized: freeze at −20 °C (−4 °F); after reconstitution, refrigerate at 2–8 °C (35.6–46.4 °F); avoid freeze–thaw cycles.

Molecular Info

Chain Length:17 amino acids
Sequence Type:Modified hGH C-terminal fragment
Molecular Weight:1,815.1 Da
Amino Acid Sequence:YLRIVQCRSVEGSCGF (Tyr-Leu-Arg-Ile-Val-Gln-Cys-Arg-Ser-Val-Glu-Gly-Ser-Cys-Gly-Phe)
Modification:hGH fragment 176-191 with N-terminal tyrosine addition; contains disulfide bond between Cys183 and Cys189

Research Indications

Fatloss

effective

Fat Loss / Lipolysis
Increases fat oxidation and reduces body weight without affecting glucose metabolism.
Lipogenesis Inhibition
Reduces fat synthesis and storage in adipose tissue.
Metabolic Safety
Does not cause hyperglycemia or insulin resistance unlike full hGH.

Joint

effective

Cartilage Repair
Combined with HA, shows enhanced cartilage regeneration in OA models.
Joint Health
Accelerated recovery in animal studies without IGF-1 stimulation.
Osteoarthritis
Synergistic effects with hyaluronic acid for joint repair.

Reconstitution

Draw 3.0 mL bacteriostatic water with a sterile syringe.
Inject slowly down the vial wall; avoid foaming.
Gently swirl/roll until dissolved (do not shake).
Label and refrigerate at 2–8 °C (35.6–46.4 °F) , protected from light.
Label and refrigerate at 2–8 °C (35.6–46.4 °F), protected from light.

Interactions

Hyaluronic Acid

Synergistic

Research shows combined AOD-9604 and HA injections are more effective for cartilage repair than either alone.

BPC-157

Compatible

Different mechanisms of action. Sometimes combined in regenerative protocols.

CJC-1295

Compatible

AOD-9604 does not affect GH axis, allowing combination with GH secretagogues.

Ipamorelin

Compatible

No known interactions. Different mechanisms - can be used together.

Semaglutide

Compatible

Different fat loss mechanisms. May have complementary effects on weight management.

Insulin

Compatible

AOD-9604 does not affect glucose metabolism or insulin sensitivity unlike full hGH.

Protocol Overview

Goal:Support reduction of fat mass and enhance fat oxidation over time[1][4].
Schedule:Daily subcutaneous injections for 8–12 weeks (extend to 16 weeks if desired).
Dose Range:300–500 mcg daily with gradual titration.
Reconstitution:3.0 mL per 2 mg vial (~0.667 mg/mL) for accurate unit measurements.
Storage:Lyophilized frozen; reconstituted refrigerated; avoid repeated freeze–thaw.

Dosage Protocols

Start:300 mcg daily for Weeks 1–4; increase to 500 mcg for Weeks 5–12 as tolerated.
Target:500 mcg daily by Week 5 and maintain through cycle completion.
Frequency:Once per day (subcutaneous).
Cycle Length:8–12 weeks; optional extension to 16 weeks.
Timing:Morning administration (fasted) is common; rotate injection sites.

Dosage Protocols

Fat loss:250-300mcgOnce daily
Enhanced fat loss:400-500mcgOnce daily
Joint support:250mcgOnce daily
Conservative start:200mcgOnce daily

Route:injectable

Storage Instructions

Lyophilized:Store at −20 °C (−4 °F) in dry, dark conditions; stable for 1+ year[5].
Reconstituted:Refrigerate at 2–8 °C (35.6–46.4 °F); use within 3–4 weeks and avoid freeze–thaw[6].

Important Notes

Practical considerations for consistency and safety.

Use new sterile insulin syringes (U‑100, 29–31 gauge); dispose in a sharps container[7].
Rotate injection sites (abdomen, thighs, upper arms) to reduce local irritation and prevent lipohypertrophy[8].
Inject slowly; wait a few seconds before withdrawing the needle.
Each 2 mg vial provides approximately 4 days of dosing at 500 mcg/day or 6–7 days at 300 mcg/day.

Reconstitution

Allow vial to reach room temperature (15-20 minutes)
Calculate required BAC water volume using calculator below
Draw BAC water into syringe
Inject slowly down vial side (not directly onto powder)
Gently swirl until dissolved (never shake vigorously)
Store reconstituted solution at 2-8°C and use within 28 days

Route:injectable

How It Works

AOD‑9604 is a modified C‑terminal fragment of human growth hormone that retains the lipolytic (fat‑reducing) domain without the growth‑promoting effects[1]. It binds to adipose tissue and triggers breakdown of stored fat while blocking new fat storage (re‑esterification) in adipocytes[4]. At the molecular level, chronic AOD‑9604 administration upregulates β3‑adrenergic receptors in fat tissue, reversing obesity‑related suppression of these fat‑burning receptors[9]. Unlike full‑length hGH, AOD‑9604 does not meaningfully elevate IGF‑1 levels or worsen glucose tolerance, making its tolerability indistinguishable from placebo in human trials[2][3].

Lifestyle Factors

Pair with a hypocaloric, protein‑forward diet tailored to energy needs; AOD‑9604 is best viewed as a supportive aid to fat loss rather than a stand‑alone solution[10].
Combine resistance training and aerobic activity to reinforce metabolic adaptations.
Prioritize sleep and stress management to support adherence and recovery.

Injection Technique

Clean the vial stopper and skin with alcohol; allow to dry completely[8].
Pinch a skinfold; insert the needle at 90° (or 45° if very little subcutaneous fat) into subcutaneous tissue[7].
Do not aspirate for subcutaneous injections; inject slowly and steadily[13].
Rotate sites systematically (abdomen at least 2 inches from navel, thighs, upper arms) to avoid lipohypertrophy[8].

Benefits and Side Effects

Benefits

Supports reductions in fat mass and increases in fat oxidation over time; clinical trials showed modest but statistically significant weight loss (approximately 2.6 kg vs. 0.8 kg placebo over 12 weeks at 1 mg/day)[10].
Preferential loss of abdominal fat observed, resembling the pattern seen with low‑dose hGH therapy[10].
Does not meaningfully raise IGF‑1 and shows a placebo‑like safety profile in human studies; no anti‑AOD9604 antibodies detected[2][3].
Emerging regenerative potential: preclinical studies suggest possible cartilage repair and bone health benefits[11][12].

Side Effects

Generally well tolerated; occasional mild injection‑site reactions (redness/itch) may occur with subcutaneous administration.

AOD-9604 (2 mg Vial)

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